Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
نویسندگان
چکیده
منابع مشابه
Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for its mechanisms of action have remained elusive, however. Here, we report that H(2)S reacts with S-nitrosothiols to form thionitrous acid (HSNO), the smallest S-nitrosothiol. These results demonstrate that, at t...
متن کاملStructure and stability of HSNO, the simplest S-nitrosothiol.
High-level ab initio calculations employing the CCSD and CCSD(T) coupled cluster methods with a series of systematically convergent correlation-consistent basis sets have been performed to obtain accurate molecular geometry and energetic properties of the simplest S-nitrosothiol (RSNO), HSNO. The properties of the S-N bond, which are central to the physiological role of RSNOs in the storage and...
متن کاملPhotoinstability of S-nitrosothiols during sampling of whole blood: a likely source of error and variability in S-nitrosothiol measurements.
BACKGROUND The determination of reference intervals for the concentration of total S-nitrosothiols (RSNOs) in blood is a highly controversial topic, likely because of the inherent instability of these species. Most currently available techniques to quantify RSNOs in blood require considerable sample handling and multiple pretreatment steps during which light exposure is difficult to completely ...
متن کاملCharacterization of the sex - dependent myocardial 1 S - nitrosothiol proteome
Characterization of the sex-dependent myocardial 1 S-nitrosothiol proteome 2 3 Qin Shao, Jonathan Fallica, Kevin M. Casin, Elizabeth Murphy, Charles 4 Steenbergen, Mark J. Kohr 5 6 Department of Cardiology, Renji Hospital, Shanghai Jiaotong University School of 7 Medicine, Shanghai, 200127, China, Department of Pathology, Johns Hopkins 8 University School of Medicine, Baltimore, MD 21205, Depar...
متن کاملCharacterization of the sex-dependent myocardial S-nitrosothiol proteome.
Premenopausal women exhibit endogenous cardioprotective signaling mechanisms that are thought to result from the beneficial effects of estrogen, which we have shown to increase protein S-nitrosylation in the heart. S-nitrosylation is a labile protein modification that increases with a number of different forms of cardioprotection, including ischemic preconditioning. Herein, we sought to identif...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2012
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja3009693